This book constitutes the thoroughly refereed proceedings of the 6th International Conference on Subject-Oriented Business Process Management, S-BPM ONE 2014, held in Eichstätt, Germany, in April 2014. The 14 application-oriented papers selected during the peer review process and included in this volume deal with a variety of topics ranging from model elicitation over strategic alignment to the application of S-BPM in different domains like software effort estimation, production planning and education.