The patient safety is the paramount factor while treating them either conservatively or surgically. Iatrogenic injuries during surgery will cause significant morbidity and may lead to mortality. Although, the improvement made in the implants, instruments and techniques of orthopedic operations today, there are considerable surgical complications occurring. At the moment, the surgery has been well acknowledged for all the fractures and orthopedic diseases in adults and children. Also, the goal of treatment of limb fractures is to restore the limb length and anatomic articular surface alignment and rotation, also to create adequate fixation for early mobilization of associated joint with minimal complications. This Book includes safety facts explaining the anatomy and characteristic techniques for the surgeon in preventing neurovascular complications in various surgical approaches of the specific bones and joints, Hand surgery, Spine surgery and also explains every detail of performing safe surgery in the field of orthopedics and trauma. To avoid the neurovascular and other serious complications, the applied knowledge with extraordinary skills is requisite for the orthopedic surgeon while doing surgeries. This Book also highlights the prevention of surgical site infection, the current ideology of antibiotic therapy in orthopedic surgery, the precise need of anatomical skills and safe operative talent of the surgeon in avoiding hazardous complications during maximum and minimal invasive orthopedic surgery. This book will be a valuable read for MBBS students, orthopedic residents and practicing orthopedic surgeons.