The book shows how simulation’s long history and close ties to industry since the third industrial revolution have led to its growing importance in Industry 4.0. The book emphasises the role of simulation in the new industrial revolution, and its application as a key aspect of making Industry 4.0 a reality – and thus achieving the complete digitisation of manufacturing and business. It presents various perspectives on simulation and demonstrates its applications, from augmented or virtual reality to process engineering, and from quantum computing to intelligent management. Simulation for Industry 4.0 is a guide and milestone for the simulation community, as well as those readers working to achieve the goals of Industry 4.0. The connections between simulation and Industry 4.0 drawn here will be of interest not only to beginners, but also to practitioners and researchers as a point of departure in the subject, and as a guide for new lines of study.