How does a smart organization model enable self-governments to lead local and regional development in a sustainable and resilient manner? What are key aspects of smart organizations impacting the success of self-governments in attracting and retaining residents, entrepreneurs, and investors? Smart organizations became a relevant construct in economic and management sciences. They supply many practical applications for self-governments and public sector organizations that are looking for effective ways to leverage their resources and capabilities in the local and regional development process. This research monograph indicates how factors of smart organizations in local administration lead to sustainable and resilient development processes. In parallel, the monograph is a practical guide for local government managers looking for the best, international practices in collecting, researching, and interpreting data for making decisions that influence the competitiveness and market position of locations they govern.