This volume contains the proceedings of the 10th International Symposium on Stabilization, Safety, and Security of Distributed Systems (SSS), held November 21–23, 2008 in Detroit, Michigan USA. SSS started as the Workshop on Self-Stabilizing Systems (WSS), which was first held at Austin in 1989. From the second WSS in Las Vegas in 1995, the - rum was held biennially, at Santa Barbara(1997),Austin (1999), Lisbon (2001), San Francisco (2003) and Barcelona (2005). The title of the forum changed to the Symposium on Self-Stabilizing Systems (SSS) in 2003. Since 2005, SSS was run annually, and in 2006 (Dallas) the scope of the conference was extended to cover all safety and security-related aspects of self-* systems. This extension followed the demand for self-stabilization in various areas of distributed c- puting including peer-to-peer networks, wireless sensor networks, mobile ad-hoc networks, robotic networks. To reffect this change, the name of the symposium changed to the International Symposium on Stabilization, Safety, and Security of Distributed Systems (SSS). This year we received 43 submissions from 13 countries. Most submissions were from the USA and France. Each submission was carefully reviewed by three to six Program Committee members with the help of external reviewers. For the first time a rebuttal phase allowed the authors to react to the reviews before the discussion of the papers with in the Program Committee. Outof the43 submissions,17 excellent papers were selected for presentation at the symposium, which corresponds to an acceptancerate of 40%. It can be noted that the highest acceptance rate was for papers with keywords sensor networks (86%), MANETs (67%), and security of sensor and mobile networks prools (67%).