Recent results from high-energy scattering and theoretical developments of string theory require a change in our understanding of the basic structure of space-time. This book is about the advancement of ideas on the shastic nature of space-time from the 1930s onward. In particular, the author promotes the concept of space as a set of hazy lumps, first introduced by Karl Menger, and constructs a novel framework for statistical behaviour at the microlevel. The various chapters address topics such as space-time fluctuation and random potential, non-local fields, and the origin of shasticity. Implications in astro-particle physics and cosmology are also explored. Audience: This volume will be of interest to physicists, chemists and mathematicians involved in particle physics, astrophysics and cosmology.