This book contains a varied collection of chapters covering pinealectomy techniques used in current neuroscience research from over 19 internationally recognized scientists. In a total of 8 chapters, this book presents general information in pinealectomy covering topics from anatomy and histology of the pineal gland in animals to the melatonin system and different surgical techniques. This book forms an essential reference for anyone working in neuroscience, from beginner students to experienced researchers since basic information on different pinealectomy procedures used in animal models can be extremely hard to find.