Determining the value of an information system for an organization is challenging, especially before the execution of the project in which the system is put into operation. Many organizations cope with problems when having to identify the potential benefits of the investment, while even more have difficulties with their quantification. An analysis, in which multiple possible investments and approaches are compared with respect to their benefits, costs and risks, is called a ‘business case’ (BC). The current frameworks that can be used to develop BCs offer too little support for the aforementioned challenges. Opportunities to improve BC frameworks, and thereby the efficiency and effectiveness of BC development, are therefore explored in this dissertation.