This book analyses how the Swedish Agency for Research Cooperation with Developing Countries (Sarec) and the Swedish International Development Cooperation Agency (Sida) have worked to promote science in low-income countries. In doing so, the book tackles challenging questions around whose knowledges and capacities count, who sets the research agenda, how knowledge resources are distributed, and how complex donor–recipient relationships serve both to address and inflate these issues. Through a discursive analysis of policy material and interviews with former directors at Sarec and Sida as well as other key persons, the book traces how perceptions of the relationship between research and development have shifted over the last five decades. Pointing to why long-term collaboration is necessary in order to contribute significantly to capacity building, as well as highlighting more general tensions relating to the production of knowledge, will be a valuable resource for advanced students and researchers of foreign aid, development cooperation and the history of science and technology.