Synaptic plasticity is the ability of the connection, or synapse, between two neurons to change in strength in response to either use or disuse of transmission over synaptic pathways. In this book, the authors present current research in the study of the cell biology, regulation and role in disease of synaptic plasticity. Topics include the involvement of zinc via crosstalk with calcium in synaptic plasticity and neurodegeneration in the hippocampus; convergent mechanisms of drug-induced and activity-dependent plasticity; neuronal calcium sensor-1 and its role in synaptic plasticity and neurological disease; Long Term Potentiation (LTP) and Long Term Depresstion (LTD) in neurological disorders; and synaptic plasticity in addiction.