Chapter 1
19F MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY IN VITRO APPLICATIONS
(Authors: Zuzanna Bober, David Aebisher, Jacek Tabarkiewicz, and Dorota Bartusik-Aebisher)
This chapter presents applications of Fluorine-19 Magnetic Resonance Imaging (19F MRI) in cancer research, tissue metabolomics, quantification of drug delivery, cellular tracking, tissue pH measurements and detection of 19F labeled cells. In this chapter, we review in vitro research applying 19F MRI and Magnetic Resonance Spectroscopy (MRS) to facilitate the synthesis, tracking and visualization of new fluorinated drug conjugates.
Chapter 2
MAGNETIC RESONANCE IMAGING GUIDED PHOTODYNAMIC THERAPY
(Authors: Lukasz Ozóg, Dorota Bartusik-Aebisher, Jacek Tabarkiewicz and David Aebisher)
In this chapter, examples of current methods of magnetic resonance imaging (MRI) guided photodynamic therapy are presented. Recent development of MRI detectable nanoparticle constructs, magnetic resonance spectroscopy (MRS) sensors, gadolinium based photosensitizers and europium singlet oxygen probes are discussed. In addition, applications of Functional MRI using a blood oxygen dependent level (BOLD) MRI in monitoring photodynamic action is also addressed.
Chapter 3
APPLICATION OF MRI TO THE STUDY OF PHARMACEUTICALS
(Authors: Zuzanna Bober, David Aebisher, Piotr Tutka, and Dorota Bartusik-Aebisher)
This chapter presents applications of MRI within the sphere of pharmacy; in particular, the use of MRI to track pharmaceuticals in vitro and in vivo noninvasively and monitoring their controlled-release is discussed.
Chapter 4
FUNCTIONAL MRI - HOW DOES IT WORK?
(Authors: Adrian Truszkiewicz, David Aebisher, Jacek Tabarkiewicz and Dorota Bartusik-Aebisher)
This chapter presents research of functional MRI for noninvasive clinical brain imaging as it is applied to studies of autism, schizophrenia, epilepsy Alzheimer's disease, Parkinson's disease, traumatic brain injury and blood oxygenation-level dependent (BOLD) imaging of brain function.. The aim of this chapter is to provide an overview of the scope of fMRI as a diagnostic technique in neurology and in neurosurgery.