16 year old twins Tripp and Iris get a phone call in the middle of the night informing them of an accident that killed their parents. The two are forced to run away as their parents' company - the Supernatural Creatures Research and Elimination Bureau - is after them. The twins know too much so it's dangerous for SCREB to have them out on the loose, lest they spill the secret of the company's existance. Unknown to anyone else, Tripp and Iris have spent the last four years raising and befriending a pair of dragons. The dragons are what will keep the twins alive, but they're some of SCREB's most targeted creatures.