The Dark Plague infection has spread rapidly across the globe! On a late evening of a deadly outbreak in Glendale, Arizona, Jonathan Strain suffers from the tragic loss of his beloved wife, Melanie. A year after Outbreak Day, he loses his sanity, eventually becoming a ruthless killer for a savage group known as the Marauders. Throughout many dark years, Jonathan has stolen, tortured, and killed alongside their leader, Tyron Morales, a ruthless man with a vision to restore order to this "new world" he desperately craves to build and control.
Eventually, Jonathan leaves them behind along with his dark past, then travels to Nevada, where he partners up with four other survivors. During their struggle for survival, they hear about a safe community in Virginia known as New Haven. As they try to escape the ruined state of Nevada, Jonathan's past catches up to him. After his capture, Jonathan suddenly finds himself responsible for a fourteen-year-old girl who joins alongside him on their journey across America. Unfortunately, their expedition will not be so easy with Tyron and the Marauders on their tails because of Jonathan's heroic actions against the group of savages.