A tumor suppressor gene is also known as an antioncogene. In the recent years of biomedical science, Tumor suppressor genes (TSGs) and their indicating structures are rapidly developing. This set of genes, are not confined only to tumor suppressing, but also play a pivotal role in many other cellular activities. This book talks about important areas of this branch, ranging from primary to explanatory discoveries. For instance, many TSG indicating channels have been talked about in this book, and both mouse and Drosophila models employed for the study of these new genes have been discussed on the basis of experimental evidence. A comprehensive account has been provided for the elaborated research of micro-RNAs in the management of tumor evolution. Furthermore, an overlook has been provided about questions related to the interference of naturally produced alloys with the development of cancer growth via TSG channels. The book also encompasses latest developments in cell reframing and stemness transition procedures monitored by TSG channels.