Today, changes and breaks are the central perspectives of analysis of the scientific history. They put institutions, acting figures, research practices and knowledge cultures in a new light and make scientific history describable. Science and politics can profit from one another. Based on Mitchell G. Ash's view that scientific changes often appear in times of political upheavals, young and established scientific historians examine in this cross-epochal book changes and breaks in scientific history. They hence explore the individual and collective design options in scientific productions.