The 87 full papers and 19 short papers presented were carefully reviewed and selected from 145 submissions. The IEA/AIE 2021 conference will continue the tradition of emphasizing on applications of applied intelligent systems to solve real-life problems in all areas. These areas include the following: Part I, Artificial Intelligence Practices: Knowledge discovery and pattern mining; artificial intelligence and machine learning; sematic, topology, and ontology models; medical and health-related applications; graphic and social network analysis; signal and bioinformatics processing; evolutionary computation; attack security; natural language and text processing; fuzzy inference and theory; and sensor and communication networks Part II, From Theory to Practice: Prediction and recommendation; data management, clustering and classification; robotics; knowledge based and decision support systems; multimedia applications; innovative applications of intelligent systems; CPS and industrial applications; defect, anomaly and intrusion detection; financial and supply chain applications; Bayesian networks; BigData and time series processing; and information retrieval and relation extraction