Attention is paid to the intellectual development of the field, with a thorough review of bibliographical references. Computational tools, in R and SAS, are developed and illustrated via examples. Exercises designed to reinforce examples are included. Features This text is intended for a graduate student in applied statistics. The course is best taken after an introductory course in statistical methodology, elementary probability, and regression. Mathematical prerequisites include calculus through multivariate differentiation and integration, and, ideally, a course in matrix algebra.