Assassins have been killing the powerful and famous for at least three thousand years. Personal ambition, revenge, and anger have encouraged many to violent deeds, like the Turkish sultan who had nineteen of his brothers strangled or the bodyguards who murdered a dozen Roman emperors. More recently have come new motives like religious and political fanaticism, revolution and liberation, with governments also getting in on the act, while many victims seem to have been surprisingly careless: Abraham Lincoln was killed after letting his bodyguard go for a drink. So, do assassinations work? Drawing on anecdote, historical evidence, and statistical analysis, delves into some of history’s most notorious acts, unveiling an intriguing cast of characters, ingenious methods of killing, and many unintended consequences.