The sun sets over New Orleans, and two brothers, John and Wayne Carter, find themselves standing in a French Quarter alleyway, their clothes stained with blood, and their minds foggy. They have no memory of how they got there or what they have done. All they can recall is a new friend, Jacques St. Germain offered them a deal - work for him, and he will give them a home, purpose, and power. As the brothers sink deeper into compelled crimes, they are plagued by nightmares and memories they can't explain. Through a romantic interest of John, the Carters seek the help of her aunt, a voodoo queen, who recognizes their plight and a danger to her own family. With guidance, they unlock memories of their past and learn about the dark rituals that they were forced to participate in. The brothers race against time to break Jacques' hold before they are turned and forced to serve him for eternity. But the old vampire is not so easily defeated, and the brothers find themselves in a final showdown with Jacques. Enter the legends and the hidden world of the Big Easy where paths intertwine with serial killers, witchcraft, and a bloodline of the dead that existed well before Prohibition in the Crescent City.