COVID-19 is an acute respiratory syndrome caused by the new coronavirus, SARS-CoV-2. This infectious disease is a zoonosis, the origin of which is still debated, that emerged in December 2019 in the city of Wuhan, in China's Hubei province. The spread of SARS-CoV-2 in China led to a pandemic, declared on March 11, 2020 by the WHO.On March 25, 2020, Mali recorded its first two epidemics, with two (2) confirmed cases. Health-care workers are exposed to the risk of transmission.We carried out a prospective study from April 1 to August 31, 2021, to assess the level of knowledge, attitude and practice of the population with regard to Coronavirus disease in Bamako's large market. We surveyed 400 people.This study revealed that the level of good knowledge of the signs and risks of transmission of the COVID-19 disease and the practice of barrier gestures is low among the population surveyed.