The two-volume set LNICST 460 and 461 constitutes the proceedings of the 18th EAI International Conference on Collaborative Computing: Networking, Applications and Worksharing, CollaborateCom 2022, held in Hangzhou, China, in October 2022. The 57 full papers presented in the proceedings were carefully reviewed and selected from 171 submissions. The papers are organized in the following topical sections: Recommendation System; Federated Learning and application; Edge Computing and Collaborative working; Blockchain applications; Security and Privacy Protection; Deep Learning and application; Collaborative working; Images processing and recognition.