At the beginning of a new era in spacecraft exploration of comets and five years after Hale-Bopp's perihelion passage these proceedings of invited and contributed papers for IAU Colloquium 186 "Cometary Science after Hale-Bopp" review the state-of-the-art knowledge on comets, the icy, dusty and most primordial left-overs of the formation disk of our own solar system.