The story of a marriage, and of two lives in science. When Conrad fails to return from a conference, Eleanor wonders if it is because of the affair she is having? Or perhaps it is because his research into transgenic monkey hearts is stalling; perhaps he is sick of having the less successful career of the two of them?  She is a leading expert in stem cell research. Their grown-up children suspect Eleanor of murdering their father; El secretly fears that what has driven Con away is his discovery of their daughter Cara’s parentage. While his family in Manchester, England, scrabble for clues and reasons, Conrad—alone, confused, and on the run from a crazed animal rights activist—loses himself in the cold foggy streets of Bologna. He revisits the stages of his long marriage to El, from the happiness of the year of Cara’s birth to the grief and anger he now feels. Both partners are forced to re-examine their relationship, and, in the process, to move closer to an understanding of what it is that matters most to each of them. is a radical, remarkably nuanced look at marriage.