This volume presents part of the proceedings of NERC 2022, with an emphasis on conservation of bio-diversity in North-east India. This is a highly challenging and involved topic due to regionally diverse physiographic, geographical and eco-climatic conditions. Henceforth, systemic and holistic frameworks are required to disseminate upon the potential of science and technology for the conservation of the region’s bio-diversity. Notable among these frameworks refers to plant, microbial and animal bio-diversity conservation, value-added product development and sharing the benefits of such research for the perspective of bio-prospects, analysing critical environmental and climatic factors and their sensitivity upon urbanization strategies. Tools that are to be deployed for such insights involve plant, animal, and microbial bioscience and biotechnology, generalized rules for product design and development and survey based strategies. Addressing relevant competent methodologies and generic pedagogies, this volume on the bio-diversity conservation in North-eastern states of India aims to demonstrate the potential of pragmatic strategies that can be applied for the bio-diversity conservation in any region of world. Thereby, opportunities for nature linked livelihood security can be sought for the long term wellbeing of the humankind and ecology.