Four topics are covered in corresponding chapters, , and . This publication starts with the agile strategic foresight of sustainable mechatronic and cyber-physical systems, moves on to the topics of system generation engineering in development processes, followed by the technical inheritance in data-driven product development. Product improvements are shown via agile experiential learning based on reverse engineering and via combination of usability and emotions. Furthermore, the development of future-oriented products in the field of biomechatronic systems, sustainable mobility systems and in situ sensor integration is shown. The overcoming of challenges in product development is demonstrated through context-adapted methods by focusing on efficiency and effectiveness, as well as designer-centered methods to tackle cognitive bias. Flow design for target-oriented availability of data and information in product development is addressed. Topics of model-based systems engineering are applied to the function-driven product development by linking model elements at all stages and phases of the product. The potential of model-based systems engineering for modular product families and engineering of multidisciplinary complex systems is shown.