This is the first book focusing specifically on the design of experiments for GLMs. Much of the research literature on this topic is at a high mathematical level, and without any information on computation. This book explains the motivation behind various techniques, reduces the difficulty of the mathematics, or moves it to one side if it cannot be avoided, and gives examples of how to write and run computer programs using R. This book is aimed at readers who have done elementary differentiation and understand minimal matrix algebra, and have familiarity with R. It equips professional statisticians to read the research literature. Nonstatisticians will be able to design their own experiments by following the examples and using the programs provided.