This book constitutes the proceedings of the 18th International Conference on Design Science Research in Information Systems and Technology, DESRIST 2023, which was held in Pretoria, South Africa, from May 31–June 2, 2023. The 29 full papers presented in this volume were carefully reviewed and selected from 81 submissions. The papers are organized in the following topical sections: Design-oriented Research for Society 5.0 (Theme Track); Design of Systems Using Emerging Technologies; Human-Centered Artificial Intelligence (HCAI); Healthcare Systems and Quality of Life; Innovation and Entrepreneurship; Emerging DSR Methods and Processes; Education and DRS; Human Safety and Cybersecurity; Co-Desing and Collective Creativity for Addressing Grand Challenges; and Sustainability and Responsible Design.