This book constitutes the proceedings of the 17th International Conference on Discovery Science, DS 2015, held in banff, AB, Canada in October 2015. The 16 long and 12 short papers presendted together with 4 invited talks in this volume were carefully reviewed and selected from 44 submissions. The combination of recent advances in the development and analysis of methods for discovering scienti c knowledge, coming from machine learning, data mining, and intelligent data analysis, as well as their application in various scienti c domains, on the one hand, with the algorithmic advances in machine learning theory, on the other hand, makes every instance of this joint event unique and attractive.