San Francisco Bay is the largest and most productive estuary on the Pacific Coast of North America. It is also home to the oldest and densest urban settlements in the American West. Focusing on human inhabitation of the Bay since Ohlone times reveals the ongoing role of nature in shaping that history. From birds to oyster pirates, from gold miners to farmers, from salt ponds to ports, this is the first history of the San Francisco Bay and Delta as both a human and natural landscape. It offers invaluable context for current discussions over the best management and use of the Bay in the face of sea level rise.