This timely volume examines the conflict between human individual life and larger forces that are not controllable. Drawing on recent literature in phenomenological and existential psychology it calls for a more nuanced understanding of the human predicament. Focusing on the co-occurring crises of climate change and the COVID-19 epidemic, it explores the nature of widespread anxiety and the long-term human consequences. It calls for an expansion of current research that would include the arts and humanities for critical insights into how this essential conflict between humanity and nature may be reconciled.