The first section, in which the reader learns how to use a variety of Mathematica commands, avoids long discussions and overly sophisticated techniques. Its aim is to provide the reader with Mathematica proficiency quickly and efficiently. The second section covers a broad range of applications in physics, engineering and applied mathematics, including Egyptian Fractions, Happy Numbers, Mersenne Numbers, Multibases, Quantum Harmonic Oscillator, Quantum Square Potential, Van der Pol Oscillator, Electrostatics, Motion of a Charged Particle inan Electromagnetic Field, Duffing Oscillator, Negative and Complex Bases, Tauhrone Curves, Kepler’s Laws, Foucault’s Pendulum, Iterated Function Systems, Public-Key Encryption, and Julia and Mandelbrot Sets. The first part - examples, not long explanations. The second part-attractive applications.