This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, , deals with the long-sought-after FcµR and the recently discovered FCRL family and TRIM21. Part II, , presents a computational model of FcεRI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, , addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, , discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, , the roles of various FcRs, including FcγRIIB and FcαRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes.