A review of the research on brain networks reveals, surprisingly, that there are just five basic pillars through which all learning takes place: Symbols, Patterns, Order, Categories, and Relationships. Dr. Tokuhama-Espinosa proposes that redesigning school curriculum around these five pillars—whether to augment or replace traditional subject categories—could enable students to develop the transdisciplinary problem-solving skills that are often touted as the ultimate goal of education. Heralding a potential paradigm shift in education, explores how aligning instruction with the brain's natural design might just be the key to improving students' learning outcomes.