In this second edition the author has extended the scope and applicability of the calculus wit original contributions and perspectives developed in the years since the first edition. A main improvement is the inclusion of globally estimated symbols, allowing a treatment of operators on noncompact manifolds. Many proofs have been replaced by new and simpler arguments, giving better results and clearer insights. The applications to specific problems have been adapted to use these improved and more concrete techniques. Interest continues to increase among geometers and operator theory specialists in the Boutet de Movel calculus and its various generalizations. Thus the book’s improved proofs and modern points of view will be useful to research mathematicians and to graduate students studying partial differential equations and pseudodifferential operators.