A genome includes all of the genetic information of an organism. It is made up of the nucleotide sequences of DNA. The complete set of non-random arrangements of functional elements within the genome is known as the genomic architecture. The architecture of the genome is crucial in gene regulation. Utilizing high-throughput techniques for 3D interaction mapping and chromatin profiling produces extensive experimental data sets that describe the structure and dynamics of the genome. The study of genomic architecture is currently a very prominent area of research that has significant applications in the study of processes such as cell development, differentiation and carcinogenesis. This book explores all the diverse aspects of genomic architecture. It presents researches and studies performed by experts across the globe. The extensive content of this book provides the readers with a thorough understanding of the subject.