Providing students with an in-depth account of the astrophysics of high energy phenomena in the Universe, the third edition of this well-established textbook is ideal for advanced undergraduate and beginning graduate courses in high energy astrophysics. Building on the concepts and techniques taught in standard undergraduate courses, this textbook provides the astronomical and astrophysical background for students to explore more advanced topics. Special emphasis is given to the underlying physical principles of high energy astrophysics, helping students understand the essential physics. Now consolidated into a single-volume treatment, the third edition has been completely rewritten. It covers the most recent discoveries in areas such as gamma-ray bursts, ultra-high energy cosmic rays and ultra-high energy gamma rays. The topics have been rearranged and streamlined to make them more applicable to a wide range of different astrophysical problems.