As advances are made to the architecture of commercial aircraft cockpits, argues that it is vitally important that these new interfaces are safely incorporated and designed in a way that is usable to the pilot. Incorporation of Human Factors is essential to ensuring that engineering developments to avionic systems are integrated such that pilots can maintain safe interactions while gaining information of value. Case study examples of various technological advancements during their early conceptual stages are given throughout to highlight how the methods and processes can be applied across each stage. The text will be useful for professionals, graduate students and academic researchers in the fields of aviation, Human Factors and ergonomics.