Interest in humor has grown in recent years, especially in relation to its clinical applications. Humor helps relax, improve relationships with others, and reduce negative emotions such as anger. A person who suffers from psychological distress, can learn to open up to others through humor, to complain less, and to transform her mood in a positive way and find constructive solutions to her problems. Mix therapeutic action can help with humor change and improve the management of several diseases (both somatic and mental). Therefore, humor can play a vital role in promoting general and mental well-being. It may seem difficult to measure the health benefits of laughter, but a number of scientific studies done in a clinical setting support the benefits of humor therapy. The aim of this book is to show how humor can become a valuable tool for working in health professions.