This book addresses several topics important to the understanding and use of data in healthcare. First, it provides a formal explanation based on epistemology (theory of knowledge) of what data actually is, what we can know about it, and how we can reason with it. The culture of data is also covered and where it fits into healthcare. Then, data quality is addressed, with a historical appreciation, as well as new concepts and insights derived from the author’s 35 years of experience in technology. The author provides a description of what healthcare data analysis is and how it is changing in the era of abundant data. Just as important is the topic of infrastructure and how it provides capability for data use. The book also describes how healthcare information infrastructure needs to change in order to meet current and future needs. The topics of artificial intelligence (AI) and machine learning in healthcare are also addressed. The author concludes with thoughts on the evolution of the role and use of data and information going into the future.