The basic building blocks are presented first, with the study of the square root of the Laplacian, and weak solutions to linear equations. Subsequently, the theory of viscosity solutions to nonlinear equations is developed, and proofs are provided for the main known results in this context. The analysis finishes with the investigation of obstacle problems for integro-differential operators and establishes the regularity of solutions and free boundaries. A distinctive feature of this work lies in its presentation of nearly all covered material in a monographic format for the first time, and several proofs streamline, and often simplify, those in the original papers. Furthermore, various open problems are listed throughout the chapters.