This book of Springer Nature is another proof of Springer’s outstanding greatness on the lively interface of Holistic Computational Optimization, Green IoTs, Smart Modeling, and Deep Learning! It is a masterpiece of what our community of academics and experts can provide when an interconnected approach of joint, mutual, and meta-learning is supported by advanced operational research and experience of the World-Leader Springer Nature! The 6th edition of International Conference on Intelligent Computing and Optimization took place at G Hua Hin Resort & Mall on April 27–28, 2023, with tremendous support from the global research scholars across the planet. Objective is to celebrate “Research Novelty with Compassion and Wisdom” with researchers, scholars, experts, and investigators in Intelligent Computing and Optimization across the globe, to share knowledge, experience, and innovation—a marvelous opportunity for discourse and mutuality by novel research, invention, and creativity. This proceedings book of the 6th ICO’2023 is published by Springer Nature—Quality Label of Enlightenment.