This book presents Proceedings of the 2021 Intelligent Systems Conference which is a remarkable collection of chapters covering a wider range of topics in areas of intelligent systems and artificial intelligence and their applications to the real world. The conference attracted a total of 496 submissions from many academic pioneering researchers, scientists, industrial engineers, and students from all around the world. These submissions underwent a double-blind peer-review process. Of the total submissions, 180 submissions have been selected to be included in these proceedings. As we witness exponential growth of computational intelligence in several directions and use of intelligent systems in everyday applications, this book is an ideal resource for reporting latest innovations and future of AI. The chapters include theory and application on all aspects of artificial intelligence, from classical to intelligent scope.