This volume contains the papers presented at the International GI/ITG C- ference on "Measurement, Modelling and Evaluation of Computing Systems" and "Dependability and Fault Tolerance," held during March 15-17, 2010 in Essen, Germany, hosted by the University of Duisburg-Essen. The Technical Committees of MMBand DFT coverallaspects ofperformanceand dependab- ityevaluationofsystemsincludingnetworks, computerarchitectures, distributed systems, software, fault-tolerant and secure systems. In 2010, both committees joined forces in a common conference MMB & DFT 2010. This current conf- ence was the 15th in a series of biannual conferences, initially started in 1981, with previous editions in Aachen, Dresden, Nuremberg and Dortmund. MMB & DFT 2010 received 42 submissions (37 regular papers and 5 tool descriptions) by authors from 15 di?erent countries. Each regular paper was reviewed by at least three (and up to ?ve) Program Committee members and external reviewers; tool papers were reviewed by two reviewers. In total we - ceived 158 reviews and the ProgramCommittee decided to accept 19 full papers and 5 tool papers. TheprogramwascompletedbytwoinvitedtalksandwewerehappythatPhil Koopman from Carnegie Mellon University and Paul Kuhn ] from the University of Stuttgart accepted to give an invited talk at the conference.