Metallurgy involves the art and science of extracting metals from their ores and modifying the metals for use. With thousands of years of development, many interdisciplinary technologies have been introduced into this traditional and large-scale industry. In modern metallurgical practices, modelling and simulation are widely used to provide solutions in the areas of design, control, optimization, and visualization, and are becoming increasingly significant in the progress of digital transformation and intelligent metallurgy. This Special Issue (SI), entitled "Metallurgical Process Simulation and Optimization", has been organized as a platform to present the recent advances in the field of modelling and optimization of metallurgical processes, which covers the processes of electric/oxygen steel-making, secondary metallurgy, (continuous) casting, and processing. Eighteen articles have been included that concern various aspects of the topic.