This book is based upon extensive data gathered over 30 years of clinical and experimental research. Internationally recognized authors share their experience and state-of-the-art knowledge in various fields of their expertise such as mihondrial cardiology, neurology, diabetology, nephrology, immunology, rheumatology, reproductive medicine, sports medicine, and chronobiology, and guide readers through the disease process, from basic biochemical mechanisms to diagnosis to therapeutic aspects. Laboratory evaluation plays a very important role in the diagnosis of mihondrial diseases, in addition to clinical assessment. This includes analysis of plasma/mihondrial coenzyme Q content, mihondrial respiratory chain function and oxidative phosphorylation in isolated mihondria and biopsy material, and nuclear magnetic resonance methods. In addition to standard medical therapy to treat cardiac, CNS, and other involvements in the mihondrial disease patients, adjunctive nutritional therapy is indicated primarily to improve mihondrial function. Therapy include coenzyme Q , a -lipoic acid, carnitine, w -3- and w -6-PUFA, vitamins and polarized light. Mihondrial Medicine is dedicated to Dr. Frederick L. Crane, discoverer of Coenzyme Q in 1957, and to the Celebration of 50 year of Coenzyme Q discovery. This book is intended for general medical practitioners, for specialists such as cardiologists, neurologists, and diabetologists, biochemists, nutritionists, pharmacists, and also for graduate students.