Large-scale chemical fertilizer application causes irreparable damage to soil structure, mineral cycles, soil microbial flora, plants, and other food chains across ecosystems, culminating in heritable mutations in future generations of consumers. A better way forward is the use of nanofertilizers to focus on macro elements (N, P, K), as switching to nanofertilizers may result in large environmental benefits by replacing the majority of these nutrients. Furthermore, the biosynthesis of nanomaterials using bacteria, algae, yeast, fungus, actinomycetes, and plants has opened up a new avenue of research in the production of inorganic nanoparticles as ecologically friendly fertilizers. Nanofertilizers should also attain increased efficiency because of a several-fold increase in the surface-to-volume ratio of nano-forms of nutrients and their suitability for foliar application, where environmental losses are further reduced. Nanostructured fertilizers can also improve nutrient use efficiency through strategies such as targeted distribution and progressive or controlled-release as they can precisely release their active molecules in response to environmental cues and biological demands. Recent research shows nanofertilizers can increase agricultural productivity by speeding up seed germination, seedling growth, photosynthetic activity, nitrogen metabolism, and carbohydrate and protein synthesis.