A bestseller, Brian Herbert and Kevin J. Anderson's is the climactic finale of the Great Schools of Dune trilogy, set 10,000 years before Frank Herbert's classic . The story line tells the origins of the Bene Gesserit Sisterhood and its breeding program, the human-computer Mentats, and the Navigators (the Spacing Guild), as well as a crucial battle for the future of the human race, in which reason faces off against fanaticism. These events have far-reaching consequences that will set the stage for , millennia later.