The total of 226 full papers presented in these proceedings was carefully reviewed and selected from 1093 submissions. The papers were organized in topical sections as follows: Part I: Theory and algorithms; Part II: Theory and algorithms; human centred computing; AI and cybersecurity; Part III: Cognitive neurosciences; reliable, robust, and secure machine learning algorithms; theory and applications of natural computing paradigms; advances in deep and shallow machine learning algorithms for biomedical data and imaging; applications; Part IV: Applications.