This imaging textbook covers in detail the beginning of neuromolecular imaging from in vivo electrochemistry. It discusses how neuromolecular imaging solved the persistent problem of electrocatalysis with empirical recording with the new imaging nanotechnology and circuits designed by the author. The BRODERICK PROBE® nanobiosensor is smaller than one strand of human hair, does not scar, and does not produce bacterial growth. These properties of the nanobiosensor have been validated by pathologists and immunologists from New York University clinical and preclinical departments. The book details this specialized sensor’s success in clinical and research settings, the biomedical engineering involved in its manufacture, and original, tried, and trusted protocols for use by scientists and practitioners in multiple fields of brain application and sensor design.