In the last two decades, Italian neurological research has experienced significant development, making a substantial contribution to the global cultural growth of Neurology. This Manual has been authored by neurologists from Sapienza University of Rome, who are experts in various fields of Neurology. Special attention has been given to diagnostic, clinical, and therapeutic aspects of different neurological disorders, including recent scientific advancements. The volume comprises 33 chapters covering topics in Neurology, Neuroradiology, and Neurosurgery, including a chapter on Neurorehabilitation, one on Pediatric Neurology, and one on Principles of Psychiatry. The Manual serves as a valuable tool for medical students, including those pursuing healthcare professions, as well as Neurology residents. It dedicates ample space to symptoms of potential neurological origin encountered in general clinical practice and the neurological conditions that clinicians must be familiar with.